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Proceedings Paper

Quantitative analysis of mucosal tissues in patients using light scattering spectroscopy
Author(s): Lev T. Perelman; George I. Zonios; Vadim Backman; Rajan S. Gurjar; Irving Itzkan; Ramachandra R. Dasari; Jacques Van Dam; Michael S. Feld
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Paper Abstract

We presented two approaches for separating a diffusive component of the backscattered signal originated in deep tissue layers and a non-diffusive single backscattering component which backscattered from a thin epithelial layer. Both approaches can be effective and have their advantages and disadvantages. The modeling technique can provide important information about hemoglobin concentration, oxygenation, and average scattering properties of the mucosal tissue. On the other hand, when applied to new tissues, it has to be adjusted to take into account tissue morphology. Also, the polarization technique can be very robust and more effective in background removal. However, it lacks extracting capabilities of the modeling technique. Both techniques can be quite valuable and compliment each other in a future clinical device.

Paper Details

Date Published: 15 July 1999
PDF: 6 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356844
Show Author Affiliations
Lev T. Perelman, Massachusetts Institute of Technology (United States)
George I. Zonios, Massachusetts General Hospital (United States)
Vadim Backman, Massachusetts Institute of Technology (United States)
Rajan S. Gurjar, Massachusetts Institute of Technology (United States)
Irving Itzkan, Massachusetts Institute of Technology (United States)
Ramachandra R. Dasari, Massachusetts Institute of Technology (United States)
Jacques Van Dam, Brigham and Women's Hospital (United States)
Michael S. Feld, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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