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Proceedings Paper

Small-volume tissue spectroscopy using photon-density waves: apparatus and technique
Author(s): Ilya V. Yaroslavsky; Albert Terenji; Stefan Willmann; Anna N. Yaroslavsky; Harald Busse; Hans-Joachim Schwarzmaier
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Paper Abstract

Optical reflectance spectroscopy of turbid media is one of promising novel techniques for diagnostics and monitoring of biological tissues. A widely used approach in the realization of this technique is the application of photon-density waves. Until recently, the frequency-domain techniques have been limited to probing relatively large volumes of tissue. Main reason for this limitation was almost exclusive use of the diffusion approximation for the interpretation of the measured data. The diffusion model becomes invalid for source-detector separations less than several transport mean free paths (approximately 5-7 mm for most of the soft tissues in the near-infrared spectral range). We have developed an inverse technique that allows data processing even at small source-detector separations. This technique is based on a frequency-domain-optiinized Monte Carlo algorithm as a light propagation model. A specially designed acceleration scheme affords using the technique as a forward method in an iterative inverse algorithm. In this paper, a description of the technique is given, and results of simulations and preliminary phantom experiments are presented.

Paper Details

Date Published: 15 July 1999
PDF: 9 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356843
Show Author Affiliations
Ilya V. Yaroslavsky, Louisiana State Univ. Medical Ctr. (United States)
Albert Terenji, Heinrich-Heine-Univ. (Germany)
Stefan Willmann, Heinrich-Heine-Univ. (Germany)
Anna N. Yaroslavsky, Louisiana State Univ. Medical Ctr. (United States)
Harald Busse, Heinrich-Heine-Univ. (Germany)
Hans-Joachim Schwarzmaier, German National Research Ctr. for Information Technology (Germany)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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