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Proceedings Paper

Multivariate method for the determination of tissue optical properties from diffuse reflectance profiles
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Paper Abstract

We present a multivariate fitting method to determine the absorption and reduced scattering coefficients of turbid biological tissue, from diffuse reflectance spatial distribution in the range of 0.4 to 2mm. This range of distance is about 0.5 to 5 times the reduced mean free path for most of the optical parameters we measure. Monte Carlo simulation provides numerical estimates of reflectance profiles for a limited set of optical parameter combinations. This forms a Òsampling gridÓ of the forward mapping from the two dimensional space of absorption and scattering coefficients to the reflectance profiles represented by N values. Through interpolation and least square fitting, in the inverse process the optical parameters can be determined with finer resolution than the sampling grid. We present a few strategies to search for the least square fit, including one step and iterative refinement. The precision of absorption and scattering coefficients is affected by the number of detection points, measurement errors, forward mapping grid points, and Monte Carlo simulation statistical errors. There is a trade-off between the resolution of optical coefficients and computation time or memory. Examples of tissue phantoms and in vivo skin optical property determination are presented.

Paper Details

Date Published: 15 July 1999
PDF: 9 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356842
Show Author Affiliations
Shu-Jen Yeh, Abbott Labs. (United States)
Omar S. Khalil, Abbott Labs. (United States)

Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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