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Proceedings Paper

Quantitative optical parameter determination in tissues using diffuse photon-density waves: the impact of measurement geometry and source modulation frequency
Author(s): Thorsten Spott; Tuan H. Pham; Lars Othar Svaasand; Joshua B. Fishkin; Bruce J. Tromberg
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Paper Abstract

The measurement of the propagation characteristics of Diffuse Photon-Density Waves (DPDW) is a viable path to determine the optical properties of tissue, i.e. the absorption and the reduced scattering coefficient. The technique allows to take measurements from bulk tissue, either by interstitial placement (infinite medium measurement) or superficial placement (semi-infinite medium measurement) of the source and detection fibers. Treatment of the tissue prior to measurement is unnecessary, such that changes to the structure of the tissue, and thus the optical properties, can be avoided. The optical properties can then be recovered by application of a diffusion model. When using a semi-infinite medium model, non-invasive in vivo measurements are feasible. While the theory is well established and verified by phantom measurements, the small amount of published data for biological tissue acquired by DPDW measurements suggests that there are still open practical problems, both concerning the measurement technique and the application of the diffusion model. In this study, we investigate the optimal choice of modulation frequencies for extracting a maximum amount of information on the scattering and absorption properties, examine different measurement setups, analyze how amplitude and phase data should be combined and compare the quality of infinite and semi-infinite medium measurements. The considerations are supported by experimental data, based on measurements from chicken and turkey breast muscle with modulation frequencies of up to 0.4 GHz.

Paper Details

Date Published: 15 July 1999
PDF: 12 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356837
Show Author Affiliations
Thorsten Spott, Norwegian Univ. of Science and Technology and Beckman Laser Institute and Medical Clinic (Germany)
Tuan H. Pham, Beckman Laser Institute and Medical Clinic (United States)
Lars Othar Svaasand, Norwegian Univ. of Science and Technology (Norway)
Joshua B. Fishkin, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)

Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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