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Proceedings Paper

Investigation of Barrett's esophagus by ultraviolet and visible fluorescence emission and excitation spectroscopy
Author(s): Alvin Katz; Paul M. Basuk; Howard E. Savage; Mark Chu; Nasser Altorki; Tom Godwin; Steven A. McCormick; Robert R. Alfano
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Paper Abstract

In this work, ultraviolet and visible emission and excitation fluorescence spectroscopy was performed on excised human gastrointestinal tissue for the purpose of determining whether fluorescence measurements can be used to detect and monitor patients with BarrettÕs esophagus. Tissue samples were acquired from eleven esophagectomy patients. For each excised esophagus, spectral measurements were taken from multiple locations of normal, malignant and, when present, suspected BarrettÕs tissue. At each site scanned, a biopsy sample was removed for histopathology and the results were correlated with spectral measurements. Differences were observed in the spectra from BarrettÕs, normal, and malignant esophageal tissue. Initial results indicate that these differences in spectra can clearly distinguish normal, BarrettÕs and malignant tissue, and may allow in vivo optical detection of dysplasia in patients with BarrettÕs esophagus during endoscopic examinations.

Paper Details

Date Published: 15 July 1999
PDF: 3 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356835
Show Author Affiliations
Alvin Katz, CUNY/City College (United States)
Paul M. Basuk, New York Hospital (United States)
Howard E. Savage, New York Eye and Ear Infirmary (United States)
Mark Chu, New York Hospital and Cornell Medical Ctr. (United States)
Nasser Altorki, New York Hospital and Cornell Medical Ctr. (United States)
Tom Godwin, New York Hospital and Cornell Medical Ctr. (United States)
Steven A. McCormick, New York Eye and Ear Infirmary (United States)
Robert R. Alfano, CUNY/City College (United States)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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