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Proceedings Paper

Quantitative imaging in time-resolved transillumination experiments using time-dependent contrast functions
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Paper Abstract

We have developed a random walk model that uses time-dependent contrast functions to quantify the crosssection and the diffusion and absorption coefficients of an optically abnormal target from time-of-flight (TOF) data obtained in time-resolved transillumination experiments1. To substantiate our methodology we have used two different sets of data. The first set of data, provided by colleagues at University College London, are TOF measurements obtained using a solid phantom whose thickness (55mm), optical properties (absorption, ?a=0.006mm-1, transport corrected scattering, ?sc'=0.7mm-1), and characteristics of its abnormal target (size=5mm, optical properties twice those of the background) are close to those of a human breast. The second set of data, provided by colleagues at Politecnico di Milan, are TOF measurements on a 50mm thick phantom (?a=0.01mm-1, ?sc'= 1mm-1) in which two 10mm abnormal targets (one abnormally scattering, ?sc'=2mm-1; one abnormally absorbing and scattering, ?a =0.04mm-1, ?sc'=2mm-1), are embedded. None of these data includes very short path photons whose measurements are clinically impractical. Using our time-dependent contrast functions, we were able to estimate the size and optical properties of the targets with an error margin of 3-25%.

Paper Details

Date Published: 15 July 1999
PDF: 5 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356834
Show Author Affiliations
Victor V. Chernomordik, National Institutes of Health (Israel)
David W. Hattery, National Institutes of Health and George Washington Univ. (United States)
Amir H. Gandjbakhche, National Institutes of Health (Israel)
Antonio Pifferi, Politecnico di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Gianluca Valentini, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Jeremy C. Hebden, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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