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Proceedings Paper

In-vivo evaluation of layered scattering coefficients and refractive indices with OCT
Author(s): Alexander R. Knuettel; Martin Boehlau-Godau; Michael Rist; Paul Welker; Uwe Gogolin; Christian Kugler
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Paper Abstract

Besides morphological images created by optical coherence tomography (OCT), further parameters are evaluated in skin tissue under in vivo conditions. Scattering coefficients and refractive indices may support tissue characterization for research and diagnostic purposes in cosmetics / pharmacy and medicine, respectively. The known Klett algorithm15 has been applied for retrieval of scattering coefficients. To permit refractive index evaluation, the sample arm of our OCT setup has been arranged to minimize mechanical adjustment of a lens within the objective. A corresponding simple algorithm has been derived. Both parameters have been measured in layered structures in skin like stratum comeum, epidermis and dermis. Significant water content in a localized sweatgland duct has been observed by refractive index evaluation.

Paper Details

Date Published: 15 July 1999
PDF: 11 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356823
Show Author Affiliations
Alexander R. Knuettel, Roche Diagnostics (Germany)
Martin Boehlau-Godau, Roche Diagnostics (Germany)
Michael Rist, Roche Diagnostics (Germany)
Paul Welker, Roche Diagnostics (Germany)
Uwe Gogolin, Roche Diagnostics (Germany)
Christian Kugler, Roche Diagnostics (Germany)

Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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