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Proceedings Paper

Estimation of the optical properties of two-layered tissue simulating phantoms from spatially resolved frequency-domain reflectance
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Paper Abstract

Spatially resolved diffuse reflectance measurements of two-layer tissue simulating phantoms were performed in the frequency-domain. The measurements were fitted to a two-layer diffusion model of photon transport. The specific case of skin containing increasing amounts of exogenous absorber over homogeneous muscle tissue was simulated. The retrieved optical properties were compared with the known optical properties of the phantoms as well as with results obtained from Monte Carlo (M.C.) simulated data. It was found that in most cases, experimental factors that are yet to be accounted for rather than diffusion theory limitations determine the accuracy of retrieved optical properties. The absorption increase in the top layer could only be quantified for a layer thickness of 4mm. The errors in all other retrieved optical properties were in the 15-40% range with estimated uncertainties to the fitted parameter values being of similar magnitude.

Paper Details

Date Published: 15 July 1999
PDF: 9 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356806
Show Author Affiliations
George Alexandrakis, Hamilton Regional Cancer Ctr. (Canada) and McMaster Univ. (Canada)
Robert A. Weersink, Photonics Research Ontario (Canada)
Jody T. Bruulsema, Hamilton Regional Cancer Ctr. (Canada) and McMaster Univ. (Canada)
Michael S. Patterson, Hamilton Regional Cancer Ctr. (Canada) and McMaster Univ. (Canada)

Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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