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Proceedings Paper

Layered Monte Carlo model for the description of diffuse reflectance spectra from pigmented skin lesions
Author(s): Vincent P. Wallace; Peter S. Mortimer; Robert J. Ott; Jeffery C. Bamber
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Paper Abstract

Diffuse reflectance measurements of pigmented lesions has been shown to provide information useful for diagnosis. This technique can provide additional information that is not available to dermatologists by visual examination alone. It is desirable however, to gain an understanding of how this information originates from the histological and structural differences within lesions. If such an understanding could be obtained particularly through an accurate theoretical model for the interaction of light with pigmented lesions, it might be possible to improve the design of the reflectance measurement system and the resulting diagnostic performance. Semi-quantitative measurements of histological sections of pigmented lesions were made of the features thought most likely to affect the optical properties. A theoretical model using a layered Monte Carlo simulation was suggested to explain the observed reflectance spectra in terms of the histological features and to better understand how the optical properties are changed due to the presence of malignancy. We found that the microscopic structure such as cell morphology, layer thickness and melanin content are associated with differing optical properties and hence reflectance spectra.

Paper Details

Date Published: 15 July 1999
PDF: 6 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356803
Show Author Affiliations
Vincent P. Wallace, Royal Marsden NHS Trust (UK) and Institute of Cancer Research (United Kingdom)
Peter S. Mortimer, Royal Marsden NHS Trust (UK) and Institute of Cancer Research (United Kingdom)
Robert J. Ott, Royal Marsden NHS Trust (UK) and Institute of Cancer Research (United Kingdom)
Jeffery C. Bamber, Royal Marsden NHS Trust (UK) and Institute of Cancer Research (United Kingdom)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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