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Proceedings Paper

Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues
Author(s): Claudia Casavola; Lelia Adelina Paunescu; Maria-Angela Franceschini; Sergio Fantini; Lew Winter; Jin Kim; Debra Wood; Enrico Gratton
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Paper Abstract

We present a novel technique based on tilting the bed where the subject is lying, to non-invasively measure the tissue blood flow (BF) and oxygen consumption (OC) with near-infrared (NIR) spectroscopy. We used a NIR, frequency domain spectrometer to measure the concentrations of oxy-hemoglobin ([HbO2]), deoxy-hemoglobin ([Hb]) and total hemoglobin (THC) in the calf muscle of human subjects. The subject was lying horizontally, and after a baseline acquisition, the bed was tilted by 10 degrees (feet down, head up). This position was kept for 1 min, then the subject was brought back to the horizontal position. This tilting procedure caused variations in the calf [Hb02], [Hb], and THC similar to those observed during a pneumatic-cuff-induced venous occlusion. The increasing rate of THC and [Hb] caused by tilting allowed the calculation of blood flow and oxygen consumption. We found a quantitative agreement between the values of BF (OC) measured with the tilting table and with the venous occlusion protocols. On the 26 subjects examined with the tilting table protocol, we found population average values of BF = 1.51 ml (100ml)-1-min-1 and OC = 6.10 ?mol( 100ml)-1 min-1.

Paper Details

Date Published: 15 July 1999
PDF: 8 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356789
Show Author Affiliations
Claudia Casavola, Univ. of Illinois/Urbana-Champaign and Univ. degli Studi di Bari (Italy)
Lelia Adelina Paunescu, Univ. of Illinois/Urbana-Champaign (United States)
Maria-Angela Franceschini, Univ. of Illinois/Urbana-Champaign (United States)
Sergio Fantini, Univ. of Illinois/Urbana-Champaign (United States)
Lew Winter, Danville Veterans Affairs Medical Ctr. (United States)
Jin Kim, Danville Veterans Affairs Medical Ctr. (United States)
Debra Wood, Danville Veterans Affairs Medical Ctr. (United States)
Enrico Gratton, Univ. of Illinois/Urbana-Champaign (United States)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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