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Proceedings Paper

New optical probe designs for absolute (self-calibrating) NIR tissue hemoglobin measurements
Author(s): Dennis M. Hueber; Sergio Fantini; Albert E. Cerussi; Beniamino B. Barbieri
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Paper Abstract

Most of the instruments reported for near infrared absorption measurements in highly scattering media, suitable for noninvasive hemoglobin concentration measurements in living tissues, require some type of instrumental calibration, or knowledge of the initial concentrations of the two species. A new type of probe, which does not require calibration, has been developed. These new probes can provide a rapid and ÒabsoluteÓ measurement of absorption and scattering in tissue when combined with the Òmulti-distanceÓ method developed, in part, at the Laboratory for Fluorescence Dynamics at the University of Illinois and ISS Incorporated. An initial evaluation of the performance and efficacy of these new probes has been performed using a frequency-domain ISS tissue oximeter. The new probes offer the convenience of not requiring calibration, and also provide more reliable measurements and greater long-term stability compared with the standard multidistance design. The new probes rely on a symmetrical arrangement of light sources and detectors. These geometries allow for measurements that are, in theory, entirely independent of the intensity differences between light sources, phase differences between the multiple light sources, sensitivity differences between the detectors, and any optical coupling losses, including those at the probe sample interface.

Paper Details

Date Published: 15 July 1999
PDF: 14 pages
Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); doi: 10.1117/12.356784
Show Author Affiliations
Dennis M. Hueber, ISS, Inc. (United States)
Sergio Fantini, Univ. of Illinois/Urbana-Champaign (United States)
Albert E. Cerussi, Univ. of Illinois/Urbana-Champaign (United States)
Beniamino B. Barbieri, ISS, Inc. (United States)


Published in SPIE Proceedings Vol. 3597:
Optical Tomography and Spectroscopy of Tissue III
Britton Chance; Robert R. Alfano; Bruce J. Tromberg, Editor(s)

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