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Proceedings Paper

Application of infrared fiber optic imaging in atherosclerotic plaques
Author(s): Bujin Guo; S. Ward Casscells; Gregory H. Bearman; Janice McNatt; Morteza Naghevi; Basit A. Malik; Khawar Gul; James T. Willerson
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Paper Abstract

Rupture of atherosclerotic plaques - the main cause of heart attach and stokes - is not predictable. Hence even treadmill stress tests fail to detect many persons at risk. Fatal plaques are found at autopsies to be associated with active inflammatory cells. Classically, inflammation is detected by its swelling, red color, pain and heat. We have found that heat accurately locates the dangerous plaques that are significantly warmer then atherosclerotic plaques without the same inflammation. In order to develop a non-surgical method of locating these plaques, an IR fiber optic imaging system has been developed in our laboratory to evalute the causes and effect of heat in atherosclerotic plaques. The fiber optical imagin bundle consists of 900 individual As2S3 chalcogenide glass fibers which transmit IR radiation from 0.7 micrometers 7 micrometers with little energy loss. By combining that with a highly sensitive Indium Antimonide IR focal plane array detector, we are able to obtain thermal graphic images in situ. The temperature heterogeneity of atherosclerotic plaques developed in the arteral of the experimental animal models is under study with the new device. The preliminary experimental results from the animal model are encouraging. The potential of using this new technology in diagnostic evaluation of the vulnerable atherosclerotic plaques is considerable.

Paper Details

Date Published: 26 July 1999
PDF: 8 pages
Proc. SPIE 3698, Infrared Technology and Applications XXV, (26 July 1999); doi: 10.1117/12.354505
Show Author Affiliations
Bujin Guo, Texas Medical Ctr. (United States)
S. Ward Casscells, Texas Medical Ctr. and Univ. of Texas/Houston (United States)
Gregory H. Bearman, ANE Image, Inc. (United States)
Janice McNatt, Univ. of Texas/Houston (United States)
Morteza Naghevi, Univ. of Texas/Houston (United States)
Basit A. Malik, Texas Medical Ctr. (United States)
Khawar Gul, Univ. of Texas/Houston (United States)
James T. Willerson, Texas HMedical Ctr. and Univ. of Texas/Houston (United States)

Published in SPIE Proceedings Vol. 3698:
Infrared Technology and Applications XXV
Bjorn F. Andresen; Marija Strojnik, Editor(s)

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