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Proceedings Paper

13CO2/12CO2 ratio analysis in exhaled air by lead-salt tunable diode lasers for noninvasive diagnostics in gastroenterology
Author(s): Eugene V. Stepanov; Pavel V. Zyrianov; Valerii A. Miliaev; Yurii G. Selivanov; Eugene G. Chizhevskii; Svetlana Os'kina; Vladimir T. Ivashkin; Elena I. Nikitina
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Paper Abstract

An analyzer of 13CO2/12CO2 ratio in exhaled air based on lead-salt tunable diode lasers is presented. High accuracy of the carbon isotope ratio detection in exhaled carbon dioxide was achieved with help of very simple optical schematics. It was based on the use of MBE laser diodes operating in pulse mode and on recording the resonance CO2 absorption at 4.2 micrometers . Special fast acquisition electronics and software were applied for spectral data collection and processing. Developed laser system was tested in a clinical train aimed to assessment eradication efficiency in therapy of gastritis associated with Helicobacter pylori infection. Data on the 13C-urea breath test used for P.pylori detection and obtained with tunable diode lasers in the course of the trail was compared with the results of Mass-Spectroscopy analysis and histology observations. The analyzer can be used also for 13CO2/12CO2 ratio detection in exhalation to perform gastroenterology breath test based on using other compounds labeled with stable isotopes.

Paper Details

Date Published: 14 July 1999
PDF: 9 pages
Proc. SPIE 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology, (14 July 1999); doi: 10.1117/12.353109
Show Author Affiliations
Eugene V. Stepanov, General Physics Institute (Russia)
Pavel V. Zyrianov, General Physics Institute (Russia)
Valerii A. Miliaev, General Physics Institute (Russia)
Yurii G. Selivanov, P.N. Lebedev Physical Institute (Russia)
Eugene G. Chizhevskii, P.N. Lebedev Physical Institute (Russia)
Svetlana Os'kina, P.N. Lebedev Physical Institute (Russia)
Vladimir T. Ivashkin, Moscow Medical Academy (Russia)
Elena I. Nikitina, Moscow Medical Academy (Russia)

Published in SPIE Proceedings Vol. 3829:
ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology
Alexander M. Prokhorov; Vladimir I. Pustovoy; Genadi P. Kuz'min, Editor(s)

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