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Proceedings Paper

Miniature silicon electronic biological assay chip and applications for rapid battlefield diagnostics
Author(s): Brian T. Cunningham; Robert A. Regan; Christopher Clapp; Eric Hildebrant; Marc S. Weinberg; John Williams
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Paper Abstract

Assessing the medical condition of battlefield personnel requires the development of rapid, portable biological diagnostic assays for a wide variety of antigens and enzymes. Ideally, such an assay would be inexpensive, small, and require no added reagents while maintaining the sensitivity and accuracy of laboratory-based assays. In this work, a microelectromechanical (MEMS) based biological assay sensor is presented which is expected to meet the above requirements. The sensor is a thin silicon membrane resonator (SMR) which registers a decrease in resonant frequency when mass is adsorbed onto its surface. By coating the sensor surface with a monolayer of antibody, for example, we have detected the corresponding antigen with a detection resolution of 0.25 ng/ml in phosphate buffer solution. Micromachining techniques are being used to integrate many (64 elements on the first test chip) identical SMR sensors into a single silicon chip which would be capable of simultaneously performing a wide variety of biomedical assays. The sensors require only a small printed circuit board and 8V power supply to operate and provide a readout. The presentation will describe the operation of the SMR sensor, the fabrication of the sensor array, and initial test results using commercially available animal immunoglobulins in laboratory-prepared test solutions.

Paper Details

Date Published: 13 July 1999
PDF: 9 pages
Proc. SPIE 3712, Battlefield Biomedical Technologies, (13 July 1999); doi: 10.1117/12.353020
Show Author Affiliations
Brian T. Cunningham, Charles Stark Draper Lab., Inc. (United States)
Robert A. Regan, Charles Stark Draper Lab.,Inc. (United States)
Christopher Clapp, Charles Stark Draper Lab., Inc. (United States)
Eric Hildebrant, Charles Stark Draper Lab., Inc. (United States)
Marc S. Weinberg, Charles Stark Draper Lab., Inc. (United States)
John Williams, Charles Stark Draper Lab., Inc. (United States)

Published in SPIE Proceedings Vol. 3712:
Battlefield Biomedical Technologies
Homer H. Pien, Editor(s)

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