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Proceedings Paper

Photodynamic therapy with ultrafast lasers
Author(s): Eric A. Wachter; Mark G. Petersen; Craig Dees
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Paper Abstract

The photodynamic properties of several photosensitive compounds have been evaluated in vivo using simultaneous two-photon excitation (TPE) and multi-photon excitation (MPE). TPE and MPE are effected using a mode-locked laser, such as the mode-locked titanium:sapphire or Nd:YLF laser, the near infrared output of which allows direct promotion of various non-resonant transitions. Such lasers are exceptionally well suited for non-linear activation of exogenous or endogenous PDT agents in biological systems due to their extremely short pulse width, modest pulse energy, and high repetition rate; these features combine to effect efficient PDT activation with minimal potential for non- specific biological damage, improved spatial localization of activation, and enhanced depth of penetration. Results in several murine models are presented.

Paper Details

Date Published: 4 June 1999
PDF: 9 pages
Proc. SPIE 3616, Commercial and Biomedical Applications of Ultrafast Lasers, (4 June 1999); doi: 10.1117/12.351822
Show Author Affiliations
Eric A. Wachter, Photogen, Inc. (United States)
Mark G. Petersen, Univ. of Tennessee (United States)
Craig Dees, Photogen, Inc. (United States)

Published in SPIE Proceedings Vol. 3616:
Commercial and Biomedical Applications of Ultrafast Lasers
Murray K. Reed; Joseph Neev, Editor(s)

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