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Proceedings Paper

Improved accuracy of quantification of analytes in human body fluids by near-IR laser Raman spectroscopy with new algorithms
Author(s): Jianan Y. Qu; On Lai Yau; SzeFong Mark Yau
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Paper Abstract

Near infrared Raman spectroscopy has been successfully used to analyze ethanol and acetaminophen in human urine samples quantitatively. The new algorithms incorporating the intrinsic spectrum of the analyte of interest into the multivariate calibration were examined to improve the accuracy of the predicted concentrations. Comparing with commonly used partial least squares calibration, it was found that the methods using the intrinsic spectrum of the analyte of interest always achieved much higher accuracy, particularly when the interference from other undesired chemicals in the samples are severe.

Paper Details

Date Published: 9 July 1999
PDF: 6 pages
Proc. SPIE 3595, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems, (9 July 1999); doi: 10.1117/12.351525
Show Author Affiliations
Jianan Y. Qu, Hong Kong Univ. of Science and Technology (Hong Kong)
On Lai Yau, Hong Kong Univ. of Science and Technology (China)
SzeFong Mark Yau, Hong Kong Univ. of Science and Technology (Hong Kong)


Published in SPIE Proceedings Vol. 3595:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron; Steven T. Charles; Richard D. Bucholz; Michael W. Vannier, Editor(s)

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