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Proceedings Paper

Optimization of 5-aminolaevulinic acid application and light excitation to ensure maximum contrast between cancerous and healthy tissue on the skin
Author(s): Tracy McKechnie; Jacqueline Hewett; Wilson Sibbett; Miles J. Padgett; Colin Clark; James Ferguson
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Paper Abstract

This paper describes a low-cost system for the illumination and real-time imaging of skin lesions. The light source is a mercury arc lamp, filtered to preferentially excite the fluorescence of protoporphyrin IX (PpIX) formed within the skin after the topical application of 5-aminolaevulinic acid (ALA). A video camera with a reduced-frame-rate, i.e. integrating, enables low intensity fluorescence imaging. Appropriate filtering provides independent images of the illumination uniformity, PpIX fluorescence and autofluorescence. Subsequent image processing yields false color images of the tissue surface illustrating the extent of ALA application, tumor boarder, surrounding satellites and the possible demarcation of treatment zones.

Paper Details

Date Published: 6 July 1999
PDF: 7 pages
Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); doi: 10.1117/12.351513
Show Author Affiliations
Tracy McKechnie, Univ. of St. Andrews (United Kingdom)
Jacqueline Hewett, Univ. of St. Andrews (United Kingdom)
Wilson Sibbett, Univ. of St. Andrews (United Kingdom)
Miles J. Padgett, Univ. of St. Andrews (United Kingdom)
Colin Clark, Ninewells Hospital (United Kingdom)
James Ferguson, Ninewells Hospital (United Kingdom)


Published in SPIE Proceedings Vol. 3592:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII
Thomas J. Dougherty, Editor(s)

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