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Proceedings Paper

Examples of adjuvant treatment enhancing the antitumor effect of photodynamic therapy
Author(s): Mladen Korbelik; Ivana Cecic; Jinghai Sun; David J. Chaplin
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Paper Abstract

Strategies for improving the clinical efficacy of photodynamic therapy (PDT) in treatment of solid cancers include applications of different types of adjuvant treatments in addition to this modality that may result in superior therapeutic outcome. Examples of such an approach investigated using mouse tumor models are presented in this report. It is shown that the cures of PDT treated subcutaneous tumors can be substantially improved by adjuvant therapy with: metoclopramide (enhancement of cancer cell apoptosis), combretastatin A-4 (selective destruction of tumor neovasculature), Roussin's Black Salt (light activated tumor localized release of nitric oxide), or dendritic cell-based adoptive immunotherapy (immune rejection of treated tumor).

Paper Details

Date Published: 6 July 1999
PDF: 8 pages
Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); doi: 10.1117/12.351507
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Agency (Canada)
Ivana Cecic, British Columbia Cancer Agency (Canada)
Jinghai Sun, British Columbia Cancer Agency (Canada)
David J. Chaplin, Gray Lab. Cancer Research Trust (United Kingdom)


Published in SPIE Proceedings Vol. 3592:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII
Thomas J. Dougherty, Editor(s)

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