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Proceedings Paper

Effects of photodynamic therapy on human glioma spheroids
Author(s): Steen J. Madsen; Chung-Ho Sun; Eugene A. Chu; Henry Hirschberg; Bruce J. Tromberg
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Paper Abstract

The poor prognosis for patients with malignant brain neoplasm has led to a search for better treatment modalities. Although gliomas are considered to be disseminated tumors in the brain, most recur at the site of the previous tumor resection. Improved local control would thus be of clear benefit. The utility of photodynamic therapy (PDT) in the treatment of brain neoplasms is investigated using a human glioma spheroid model. Specifically, the effects of PDT on human glioma spheroids are investigated using PhotofrinTM and 56-aminolevulinic acid (ALA). The effects of various irradiation schemes were monitored using a simple growth assay. A growth delay was observed at an optical fluence of approximately 35 J cm-2 for spheroids incubated in Photofrin. Spheroids incubated in ALA were unaffected by the PDT treatment regimens examined in this study. This was most likely a result of inadequate photosensitizer concentration.

Paper Details

Date Published: 6 July 1999
PDF: 8 pages
Proc. SPIE 3592, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII, (6 July 1999); doi: 10.1117/12.351505
Show Author Affiliations
Steen J. Madsen, Univ. of Nevada/Las Vegas (United States)
Chung-Ho Sun, Beckman Laser Institute and Medical Clinic (United States)
Eugene A. Chu, Beckman Laser Institute and Medical Clinic (United States)
Henry Hirschberg, Norwegian Radium Hospital (Norway)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 3592:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VIII
Thomas J. Dougherty, Editor(s)

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