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Proceedings Paper

Multipixel frequency-domain imaging of spontaneous canine breast disease using fluorescent contrast agents
Author(s): Jeffery S. Reynolds; Alan B. Thompson; Tamara L. Troy; Ralf H. Mayer; David J. Waters; Eva Marie Sevick-Muraca
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Paper Abstract

In this paper we demonstrate the ability to detect the frequency-domain fluorescent signal from the contrast agent indocyanine green within the mammary chain of dogs with spontaneous mammary tumors. We use a gain-modulated image intensifier to rapidly capture multi-pixel images of the fluorescent modulation amplitude, modulation phase, and average intensity signals. Excitation is provided by a 100 MHz amplitude-modulated, 780 nm laser diode. Time series images of the uptake and clearance of the contrast agent in the diseased tissue are also presented.

Paper Details

Date Published: 2 July 1999
PDF: 6 pages
Proc. SPIE 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation, (2 July 1999); doi: 10.1117/12.351035
Show Author Affiliations
Jeffery S. Reynolds, Purdue Univ. (United States)
Alan B. Thompson, Purdue Univ. (United States)
Tamara L. Troy, Purdue Univ. (United States)
Ralf H. Mayer, Purdue Univ. (United States)
David J. Waters, Purdue Univ. (United States)
Eva Marie Sevick-Muraca, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 3600:
Biomedical Imaging: Reporters, Dyes, and Instrumentation
Eva Marie Sevick-Muraca; Darryl J. Bornhop; Christopher H. Contag; Eva Marie Sevick-Muraca, Editor(s)

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