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Proceedings Paper

Diagnostics of breast cancer tissue by fiber optic evanescent wave Fourier transform IR (FEW-FTIR) spectroscopy
Author(s): Natalia I. Afanasyeva; Volodymyr Makhine; Reinhard F. Bruch
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Paper Abstract

Fourier transform IR fiberoptic evanescent wave (FTIR-FEW) spectroscopy has been suggested as a powerful tool for clinical diagnostics of normal, pre-cancerous, and cancerous breast tissue ex vivo and in vitro in the middle IR region of the spectrum(850-1850 cm-1). This method is suitable for noninvasive and direct measurements of the spectra of normal and pathological tissues in vitro, ex vivo and in vivo. For the first time this method has been use nondestructively, rapidly, fast (15-20 sec) and remotely in the operating rooms of clinics. The aim of our studies has been the on-line testing of various tumor tissues during surgery to optimize and localize an area to remove tissue. We measured very small samples of normal and malignant breast tissue ex vivo with a fiber bent to a special angle, forming a special tip probe configuration. We also suggest here the minimally invasive FTIR-FEW diagnosis tool using 'needle' changeable tip probe for biopsy applications. The corresponding spectral histopathology scheme could be developed with help of this technique in vitro. The breast tissue at different stages of tumor or cancer has been distinguished very clearly in spectra of amide, cyclic and non-cyclic hydrogen bonded fragments, phosphate groups and sugars.

Paper Details

Date Published: 22 June 1999
PDF: 12 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.351003
Show Author Affiliations
Natalia I. Afanasyeva, Univ. of Nevada/Reno and Institute of Spectroscopy (United States)
Volodymyr Makhine, Institute of Spectroscopy (United States)
Reinhard F. Bruch, Univ. of Nevada/Reno (United States)

Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory M.D.; R. Rox Anderson M.D.; David S. Robinson M.D.; Reza S. Malek M.D.; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels D.V.M.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; C. Gaelyn Garrett M.D.; Eugene A. Trowers M.D.; Aaron P. Perlmutter M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Darryl J. Bornhop; C. Gaelyn Garrett M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Harvey Lui M.D.; Reza S. Malek M.D.; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D., Editor(s)

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