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Proceedings Paper

Mathematical analysis of the temperature field during ex-vivo and in-vivo experimental laser interstitial thermotherapy (LITT) in breast tissue models
Author(s): Fabrice Manns; Peter J. Milne; Nelson Salas; Nish Pandya; David B. Denham; Jean-Marie A. Parel; David S. Robinson
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Paper Abstract

Purpose: Laser interstitial thermotherapy is a promising minimally- invasive technique for the treatment of small cancers of the breast that are currently removed surgically lumpectomy. The purpose of this work was to analyze in situ temperature fields recorded with stainless-steel thermocoupled probes during experimental laser interstitial thermo-therapy (LITT). Methods: Both a CW Nd:YAG laser system emitting 20W for 25 to 30s and a 980 nm diode laser emitting 10 to 20 W for up to 1200s delivered through a fiber-optic probe were used to create localized heating in fatty cadaver pig tissue and milk as phantoms. To quantify an artifact due to direct heating of the thermocouple probes by laser radiation, experiments were also performed in air, water and intralipid solution. The temperature field around the fiber-optic probe during laser irradiation was measured every 0.3 s or 1 s with an array of up to fifteen needle thermocoupled probes. The effect of light absorption by the thermocouples probes was quantified and the time-dependence of the temperature distribution was analyzed. Results: After removal of the thermocouple artifact, the temperature was found to vary exponentially with time with a time constant of 600 to 700 s. Conclusions:The time-dependence of the interstitial temperature can be modeled by exponential functions both during ex vivo and in vivo experiments.

Paper Details

Date Published: 22 June 1999
PDF: 7 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.351000
Show Author Affiliations
Fabrice Manns, Univ. of Maimi and Bascom Palmer Eye Institute/Univ. of Miami (United States)
Peter J. Milne, Univ. of Maimi (United States)
Nelson Salas, Univ. of Maimi and Bascom Palmer Eye Institute/Univ. of Miami (United States)
Nish Pandya, Univ. of Maimi and Bascom Palmer Eye Institute/Univ. of Miami (United States)
David B. Denham, Bascom Palmer Eye Institute/Univ. of Miami (United States)
Jean-Marie A. Parel, Univ. of Maimi and Bascom Palmer Eye Institute/Univ. of Miami (United States)
David S. Robinson, St. Luke's Hospital (United States)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory; R. Rox Anderson; David S. Robinson; Reza S. Malek; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels; Hans-Dieter Reidenbach; Lloyd P. Tate; C. Gaelyn Garrett; Eugene A. Trowers; Aaron P. Perlmutter; Kenneth Eugene Bartels; Lawrence S. Bass; Darryl J. Bornhop; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers, Editor(s)

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