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Proceedings Paper

Dynamic light scattering as an objective noninvasive method in veterinary ophthalmic diagnosis and research
Author(s): Stephen Dubin; Rafat R. Ansari; Orien Tulp; Sheldon Steinberg; Seth Koch; Michael A. DellaVecchia; Mihaela Cozmi; Mary Victor
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Paper Abstract

The absence of verbal feedback, available from most human patients, is a major limitation in veterinary diagnosis in general and in the evaluation of ophthalmic lens opacity in particular. A novel compact dynamic light scattering (DLS) instrument, developed at NASA, offers significant mitigation to this limitation. It not only yields objective repeatable non-invasive estimation of lens opacity but also provides insight into the nature of chemical and physical alternations in the lens and other eye structures. For example, DLS measurements of the cataractous lens may be interpreted in terms of alpha crystalline protein size. In contrast to most conventional methods, the examination results are numerical and readily accommodate statistical analysis. We present results of DLS measurements in laboratory rabbits with naphthalene induced cataracts, rodents with genetically conditioned hypertension and/or diabetes mellitus; as well as applications of the DLS method in clinical veterinary patients. Use of DLS in examination of phacoemulsification fluid, urine and other biological materials, and potential applications in ocular toxically will also be discussed.

Paper Details

Date Published: 22 June 1999
PDF: 8 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350982
Show Author Affiliations
Stephen Dubin, Drexel Univ. School of Biomedical Engineering, Science, and Health Systems (United States)
Rafat R. Ansari, NASA Lewis Research Ctr. (United States)
Orien Tulp, Drexel Univ. (United States)
Sheldon Steinberg, Univ. of Pennsylvania School of Veterinary Medicine (United States)
Seth Koch, Univ. of Pennsylvania School of Veterinary Medicine (United States)
Michael A. DellaVecchia, Drexel Univ. School of Biomedical Engineering, Science, and Health Systems (United States)
Mihaela Cozmi, Drexel Univ. School of Biomedical Engineering, Science, and Health Systems (United States)
Mary Victor, Drexel Univ. School of Biomedical Engineering, Science, and Health Systems (United States)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory; R. Rox Anderson; David S. Robinson; Reza S. Malek; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels; Hans-Dieter Reidenbach; Lloyd P. Tate; C. Gaelyn Garrett; Eugene A. Trowers; Aaron P. Perlmutter; Kenneth Eugene Bartels; Lawrence S. Bass; Darryl J. Bornhop; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers, Editor(s)

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