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Proceedings Paper

Comparison of in-vivo skin models for near-infrared laser exposure
Author(s): Thomas A. Eggleston; Michael A. Mitchell; Thomas E. Johnson; Robert L. Becker Jr.; William P. Roach
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Paper Abstract

Current safety standards for lasers operating in the 1400 to 10,000 nm wavelength region are based on few observations at specific wavelengths using in vivo models that may not represent an accurate correlation to human integument. Based on experimental results conducted with Yorkshire pigs, these standards may not accurately reflect the potential for laser injury when humans are exposed to these wavelengths. It is our belief that one of the primary damage mechanisms involved in these laser injuries is due to energy absorption by skin pigmentation, or melanin. Qualitatively, Yorkshire pigs lack melanin in their skin when compared to a more highly pigmented animal, such as the Yucatan minipig. It is hypothesized that the Yucatan minipig is a more appropriate model for pigmented human skin. By comparing histologic samples taken from various locations on Yucatan minipigs and Yorkshire pigs, and comparing these to potential locations of skin exposure on humans, we present a discussion for the establishment of more appropriate locations for in vivo laser exposure studies.

Paper Details

Date Published: 22 June 1999
PDF: 5 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350981
Show Author Affiliations
Thomas A. Eggleston, Uniformed Services Univ. of the Health Sciences (United States)
Michael A. Mitchell, Uniformed Services Univ. of the Health Sciences (United States)
Thomas E. Johnson, Uniformed Services Univ. of the Health Sciences (United States)
Robert L. Becker Jr., Armed Force Institute of Pathology (United States)
William P. Roach, Uniformed Services Univ. of the Health Sciences (United States)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory M.D.; R. Rox Anderson M.D.; David S. Robinson M.D.; Reza S. Malek M.D.; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels D.V.M.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; C. Gaelyn Garrett M.D.; Eugene A. Trowers M.D.; Aaron P. Perlmutter M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Darryl J. Bornhop; C. Gaelyn Garrett M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Harvey Lui M.D.; Reza S. Malek M.D.; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D., Editor(s)

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