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Proceedings Paper

Simulations of laser thrombolysis
Author(s): Edward J. Chapyak; Robert P. Godwin
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Paper Abstract

We have shown that bubble expansion and collapse near the interface between two materials with modest property differences produces jet-like interpenetration of the two materials. The bubble dynamics at a water-viscous fluid interface is compared with that at the interface of water with a weak elastic-plastic material. We find that, despite rather similar behavior during bubble growth and the initial portion of bubble collapse, the terminal jetting behavior is quite different, even in direction. The elastic-plastic properties chosen are representative of real and surrogate thrombus. Simulations using the elastic-plastic model agree quantitatively with laboratory thrombolysis mass-removal experiments. In our earlier simulations of laboratory experiments, walls have been remote so a to not affect the dynamics. Here we present 2D simulations of thrombolysis with water over elastic-plastic surrogate thrombus in a geometry representative of the clinical situation. The calculations include thin cylindrical elastic walls with properties and dimensions appropriate for arteries. The presence of these artery walls does not substantially change the interface jetting predicted in unconfined simulations.

Paper Details

Date Published: 22 June 1999
PDF: 8 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350979
Show Author Affiliations
Edward J. Chapyak, Los Alamos National Lab. (United States)
Robert P. Godwin, Los Alamos National Lab. (United States)

Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory; R. Rox Anderson; David S. Robinson; Reza S. Malek; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels; Hans-Dieter Reidenbach; Lloyd P. Tate; C. Gaelyn Garrett; Eugene A. Trowers; Aaron P. Perlmutter; Kenneth Eugene Bartels; Lawrence S. Bass; Darryl J. Bornhop; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers, Editor(s)

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