Share Email Print
cover

Proceedings Paper

Infrared free-electron-laser ablation of cholesterol esters in an arteriosclerotic region
Author(s): Kunio Awazu; Yuko Fukami
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Successful removal of cholesterol ester which is specifically accumulated in the arteriosclerotic region on the arterial walls was achieved by the exposure of 5.75 μm-IR free-electron-lasers (FEL) which is absorbed by C=O stretching vibrations of ester. In this study, chemical bond-changes and decrease in amount of cholesteryl oleate in IRFEL photodynamic processes were examined by Fourier transform IR microspectroscopy (FTIR). We found that the exposure of 5.75μm-FELs induces not only dissociation of ester (RCOOR') bonds but also the oxidation process of the ester (RCOOR') bonds to aldehyde (RCHO) carboxylic acid (RCHOOH), carboxylate (RCOO-) or ketone (R2C=O) bonds. Further, we exposed cholesteryl oleate to FELs having wavelength of 5.75μm, 9.40μm and 8.44μm. From changes in absorbance and thickness of the samples, we calculated quantum efficiency Φ for decrease of ester bonds and C-C chains for each wavelength-FEL exposure. Φ was obtained to be 2.1 X 10-4 for ester bond and 1.2 X 10-4 for C-C chain by 5.75μm-FELs, 0.9x10-4 and 2.0x10-4 by 9.40μm- FELs, and 1.2x10-4 and 1.0x10-4 by 8.44μm-FELs. Thus, we can conclude that removal of cholesteryl oleate by IR-FELs has the wavelength sensitivity coming from correspondence between the bonds which absorbs FEL photons and which aimed to remove.

Paper Details

Date Published: 22 June 1999
PDF: 8 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350977
Show Author Affiliations
Kunio Awazu, Free Electron Laser Research Institute, Inc. (Japan)
Yuko Fukami, Osaka Prefecture Univ. (Japan)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory M.D.; R. Rox Anderson M.D.; David S. Robinson M.D.; Reza S. Malek M.D.; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels D.V.M.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; C. Gaelyn Garrett M.D.; Eugene A. Trowers M.D.; Aaron P. Perlmutter M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Darryl J. Bornhop; C. Gaelyn Garrett M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Harvey Lui M.D.; Reza S. Malek M.D.; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D., Editor(s)

© SPIE. Terms of Use
Back to Top