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Proceedings Paper

Infrared free-electron-laser ablation of cholesterol esters in an arteriosclerotic region
Author(s): Kunio Awazu; Yuko Fukami
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Paper Abstract

Successful removal of cholesterol ester which is specifically accumulated in the arteriosclerotic region on the arterial walls was achieved by the exposure of 5.75 μm-IR free-electron-lasers (FEL) which is absorbed by C=O stretching vibrations of ester. In this study, chemical bond-changes and decrease in amount of cholesteryl oleate in IRFEL photodynamic processes were examined by Fourier transform IR microspectroscopy (FTIR). We found that the exposure of 5.75μm-FELs induces not only dissociation of ester (RCOOR') bonds but also the oxidation process of the ester (RCOOR') bonds to aldehyde (RCHO) carboxylic acid (RCHOOH), carboxylate (RCOO-) or ketone (R2C=O) bonds. Further, we exposed cholesteryl oleate to FELs having wavelength of 5.75μm, 9.40μm and 8.44μm. From changes in absorbance and thickness of the samples, we calculated quantum efficiency Φ for decrease of ester bonds and C-C chains for each wavelength-FEL exposure. Φ was obtained to be 2.1 X 10-4 for ester bond and 1.2 X 10-4 for C-C chain by 5.75μm-FELs, 0.9x10-4 and 2.0x10-4 by 9.40μm- FELs, and 1.2x10-4 and 1.0x10-4 by 8.44μm-FELs. Thus, we can conclude that removal of cholesteryl oleate by IR-FELs has the wavelength sensitivity coming from correspondence between the bonds which absorbs FEL photons and which aimed to remove.

Paper Details

Date Published: 22 June 1999
PDF: 8 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350977
Show Author Affiliations
Kunio Awazu, Free Electron Laser Research Institute, Inc. (Japan)
Yuko Fukami, Osaka Prefecture Univ. (Japan)

Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory M.D.; R. Rox Anderson M.D.; David S. Robinson M.D.; Reza S. Malek M.D.; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels D.V.M.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; C. Gaelyn Garrett M.D.; Eugene A. Trowers M.D.; Aaron P. Perlmutter M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Darryl J. Bornhop; C. Gaelyn Garrett M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Harvey Lui M.D.; Reza S. Malek M.D.; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D., Editor(s)

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