Share Email Print
cover

Proceedings Paper

Effects of transmyocardial laser revascularization using a prototype pulsed CO2 laser on contractility and perfusion of chronically ischemic myocardium in a porcine model
Author(s): Yasmin Wadia M.D.; Ali Khaki; Michio Kajitani M.D.; Yoshiki Mori M.D.; Timothy Irvine M.D.; David Sahn M.D.; Michael J. Yessik; Deborah T. Bahlman R.N.; Anthony Furnary M.D.; Kenton W. Gregory M.D.
Format Member Price Non-Member Price
PDF $17.00 $21.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The purpose of this study was to test a new prototype pulsed CO2 laser to be used for transmyocardial laser revascularization (TMR). We want to determine whether it can reduce thermal damage and mitigate induced ischemia with improvement in contractile reserve of the heart as evidenced by contrast echocardiography at rest and under dobutamine stress. TMR is an emerging surgical strategy for treatment of myocardial ischemia not amenable to conventional percutaneous or surgical revascularization. Eleven pigs underwent amaroid occulder placement on the origin of the circumflex coronary artery. Six weeks laser occlusion of the circumflex coronary artery was documented. TMR was then done on ten pigs using a prototype pulsed CO2 laser that delivered 8-12 joules energy in 1.5ms with a spot sizes of 1mm. Six weeks after TMR the pigs were restudied and sacrificed. The animals developed significant ischemia after six weeks of ameroid occlusion, at rest (p=0.01) and at peak stress (p=0.004). Wall motion for the ischemic segments improved significantly six weeks after TMR at peak stress (p=0.02). TMR results in an improvement in wall motion in our model of chromic ischemia and improves WMSI significantly during induced stress than at rest.

Paper Details

Date Published: 22 June 1999
PDF: 12 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350975
Show Author Affiliations
Yasmin Wadia M.D., Oregon Laser Ctr. and Providence St. Vincent's Hospital (United States)
Ali Khaki, Oregon Laser Ctr. and Providence St. Vincent's Hospital (United States)
Michio Kajitani M.D., Oregon Laser Ctr. and Providence St. Vincent Hospital (United States)
Yoshiki Mori M.D., Oregon Health Sciences Univ. (United States)
Timothy Irvine M.D., Oregon Health Sciences Univ. (United States)
David Sahn M.D., Oregon Health Sciences Univ. (United States)
Michael J. Yessik, CircuLase LLC (United States)
Deborah T. Bahlman R.N., Oregon Medical Laser Ctr. and Providence St. Vincent's Hospital (United States)
Anthony Furnary M.D., Oregon Medical Laser Ctr. and Providence St. Vincent's Hospital (United States)
Kenton W. Gregory M.D., Oregon Medical Laser Ctr. and Providence St. Vincent's Hospital (United States)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory M.D.; R. Rox Anderson M.D.; David S. Robinson M.D.; Reza S. Malek M.D.; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels D.V.M.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; C. Gaelyn Garrett M.D.; Eugene A. Trowers M.D.; Aaron P. Perlmutter M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Darryl J. Bornhop; C. Gaelyn Garrett M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias; Harvey Lui M.D.; Reza S. Malek M.D.; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D., Editor(s)

© SPIE. Terms of Use
Back to Top