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Proceedings Paper

Capabilities of optical coherence tomography in laryngology
Author(s): Andrei Shakhov; Anna Terentjeva; Natalia D. Gladkova; Ludmila Snopova; Yuri Chumakov; Felix I. Feldchtein; Valentin M. Gelikonov; Grigory V. Gelikonov; Alexander M. Sergeev
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Paper Abstract

We present first result of using the optical coherence tomography (OCT) in complex clinical studies in laryngology. Mucosa of the upper and middle portions of larynx is of special interest for OCT applications: it is clinically important, easily accessed by an endoscopic OCT probe, and possesses a well defined and rich tomographic structure. We have examined several tens of patients with abnormalities in vocal folds. The diagnosis was made based on clinical data including laryngoscopy and finally confirmed morphologically. When examining larynx mucosa, an endoscopic OCT probe has been introduced through a standard laryngoscope lumen, so that OCT imaging has been performed in parallel with visual observation. The OCT studies have demonstrated that in comparison with stratified healthy mucosa, carcinomatous regions have no tomographically differentiated structure, thus allowing one to exactly define the border of a tumor. Vocal nodules are imaged as poorly scattering regions without clear boundaries under preserved epithelium. Cysts of gland mucosa are seen with OCT as sharply delineated shadows at the depth of several hundred micrometers. We have also examined several patients with carcinoma after a course of radiation therapy and observed different changes in OCT images of adjoining epithelium corresponding to metaplasia, hyperplasia, and sclerosis.

Paper Details

Date Published: 22 June 1999
PDF: 11 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350971
Show Author Affiliations
Andrei Shakhov, Nizhny Novgorod Medical Academy (Russia)
Anna Terentjeva, Nizhny Novgorod Medical Academy (Russia)
Natalia D. Gladkova, Nizhny Novgorod Medical Academy (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Yuri Chumakov, Nizhny Novgorod Regional Hospital (Russia)
Felix I. Feldchtein, Institute of Applied Physics (United States)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Alexander M. Sergeev, Institute of Applied Physics (Russia)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory; R. Rox Anderson; Kenneth Eugene Bartels; Lawrence S. Bass; Darryl J. Bornhop; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; David S. Robinson; Hans-Dieter Reidenbach; Reza S. Malek; Aaron P. Perlmutter; Lou Reinisch; C. Gaelyn Garrett; Darryl J. Bornhop; Eugene A. Trowers; Kenneth Eugene Bartels; Lloyd P. Tate, Editor(s)

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