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Proceedings Paper

Wound repair in rat urinary bladder following electrocautery or holmium laser incision
Author(s): Giordano Venzi; Franz R. Schmidlin; Giulio Gabbiani; Guy P. Delacretaz; Brigitte Pittet; Hans-Juerg Leisinger; Christoph E. Iselin
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Paper Abstract

Woundhealing is a complex phenomenon which varies according the type of tissue but is also depending from the type of tissue injury. Electrocautery mainly induces coagulation necrosis while thermal damages induced by the Holmium laser primarily lead to tissue vaporization which may induce less tissue injury. The aim of this study was to evaluate the healing process of the Holmium laser induced lesions compared to electrocautery induced lesions in urothelial tissue by assessing the inflammatory response and myofibroblast behavior in sequential healing phases. A surgical wound was created in the urinary rat bladder of 32 rats either by electrocautery or by laser (N=16). The inflammatory response, the total lesion depth and the myofibroblast activity during woundhealing was then analyzed on a qualitative basis on days 0/2/4/8. The overall inflammatory response was comparable in both groups up to days two and four. However, at day eight less cellular inflammatory reaction and less myofibroblast activity was found in the specimen of lesions created by the Holmium laser. These results suggest that wound repair may be a less invasive process after Holmium laser than electrocautery.

Paper Details

Date Published: 22 June 1999
PDF: 3 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350961
Show Author Affiliations
Giordano Venzi, Univ. Hospital Geneva (Switzerland)
Franz R. Schmidlin, Univ. Hospital Geneva (Switzerland)
Giulio Gabbiani, Univ. of Geneva (Switzerland)
Guy P. Delacretaz, Ecole Polytechnique Federale de Lausanne (Switzerland)
Brigitte Pittet, Div. of Plastic and Reconstructive Surgery (Switzerland)
Hans-Juerg Leisinger, Univ. Hospital Lausanne (Switzerland)
Christoph E. Iselin, Univ. Hospital Geneva (Switzerland)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory; R. Rox Anderson; David S. Robinson; Reza S. Malek; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels; Hans-Dieter Reidenbach; Lloyd P. Tate; C. Gaelyn Garrett; Eugene A. Trowers; Aaron P. Perlmutter; Kenneth Eugene Bartels; Lawrence S. Bass; Darryl J. Bornhop; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers, Editor(s)

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