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Proceedings Paper

Transurethral photodynamic therapy in benign prostatic hyperplasia : a canine pilot study using benzoporphyrin derivative
Author(s): Sugandh D. Shetty; James O. Peabody; Elsa R. Beck; Joseph C. Cerny; Mahul B. Amin; Anna M. Richter
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Paper Abstract

Photodynamic therapy (PDT) principles were evaluated in management of benign prostatic hyperplasia (BPH) in a canine model. Five dogs were injected with benzoporphyrin derivative (BPD) and samples of prostate, bladder, urethra and rectum were taken at 1, 2, 3 and 4 hours and analyzed for BPD. Next, 16 dogs were treated with 100 Joules at 690 nm light form argon dye laser 1 hour after administration of BPD at 0.5 mg/kg using cylindrical diffuser tip fiber passed transurethrally. The prostates were harvested weekly up to 4 weeks and the size of the lesion was measured and the prostates were examined. Prostate had the highest BPD levels. Hemorrhagic lesion of 2.5 cm in diameter was noted at 1 week after PDT. At 3 and 4 weeks there were changes of glandular atrophy in the periurethral region. Minimally invasive technique of transurethral PDT causes glandular and stromal changes in the periurethral zone and has potential in the treatment of BPH.

Paper Details

Date Published: 22 June 1999
PDF: 5 pages
Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); doi: 10.1117/12.350957
Show Author Affiliations
Sugandh D. Shetty, Henry Ford Hospital (United States)
James O. Peabody, Henry Ford Hospital (United States)
Elsa R. Beck, Henry Ford Hospital (United States)
Joseph C. Cerny, Henry Ford Hospital (United States)
Mahul B. Amin, Henry Ford Hospital (United States)
Anna M. Richter, QLT Photo Therapeutics Inc. (Canada)


Published in SPIE Proceedings Vol. 3590:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
Kenton W. Gregory; R. Rox Anderson; David S. Robinson; Reza S. Malek; Lou Reinisch; Darryl J. Bornhop; Kenneth Eugene Bartels; Hans-Dieter Reidenbach; Lloyd P. Tate; C. Gaelyn Garrett; Eugene A. Trowers; Aaron P. Perlmutter; Kenneth Eugene Bartels; Lawrence S. Bass; Darryl J. Bornhop; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; Aaron P. Perlmutter; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers, Editor(s)

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