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Proceedings Paper

In-vivo tissue response to the free-electron laser
Author(s): Cynthia A. Toth; Eric Kelvin Chiu; Katrina P. Winter; Michelle L. Norton McCall; Sarah F. Bailey; Susanne Hauger
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Paper Abstract

Purpose: We analyzed the effect of energy and rate of cutting on the in vivo ocular response to 2.94 μm wavelength Free Electron Laser incision of the cornea. We were interested in the difference between our clinical observations of the initial laser lesion and the ocular response using the biomicroscope versus optical coherence tomographs. We were also interested in the difference between these clinical in vivo data and our findings from light micrographs of fixed tissue. Methods: Corneas were incised with FEL at 2.94 μm wavelength and either 2.5 or 3.5 mJ/1.4 μsec. the rate of movement of the laser beam across tissue ranged from 0.2 mm/sec to 1.2 mm/sec. Eyes were examined for two hours postoperatively using optical coherence tomography (OCT) and compared to the clinical slit lamp examination and to light microscopic examination of fixed tissue sections. Results: OCT revealed a dramatic fibrin response directly correlated to the slow sweep of the FEL beam across the tissue (longer duration of tissue exposure to the laser beam). The OCt was better than examination at the slit lamp at demonstrating sites of fibrin attachments.

Paper Details

Date Published: 18 June 1999
PDF: 11 pages
Proc. SPIE 3591, Ophthalmic Technologies IX, (18 June 1999); doi: 10.1117/12.350613
Show Author Affiliations
Cynthia A. Toth, Duke Univ. Medical Ctr. (United States)
Eric Kelvin Chiu, Duke Univ. Medical Ctr. (United States)
Katrina P. Winter, Duke Univ. Medical Ctr. (United States)
Michelle L. Norton McCall, Duke Univ. Medical Ctr. (United States)
Sarah F. Bailey, Duke Univ. Medical Ctr. (United States)
Susanne Hauger, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 3591:
Ophthalmic Technologies IX
Bruce E. Stuck; Pascal O. Rol; Michael Belkin; Karen Margaret Joos; Fabrice Manns; Bruce E. Stuck; Michael Belkin, Editor(s)

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