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Proceedings Paper

Determination of single-pulse exposure threshold (ED50) for cornea for 1400- to 2000-nm lasers
Author(s): Thomas E. Johnson; Thomas A. Eggleston; David J. Fletcher; Ken Lopez; Pedro J. Rico; Michael A. Mitchell; William P. Roach
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Paper Abstract

We report on preliminary work undertaken to determine ED50 thresholds for both skin and cornea exposure from 1400 to 2000 nm laser light. Work presented here is focused initially on 1540 nm exposures to both human skin and cornea. Light microscopy and confocal microscopy used to help understand the type of photon-tissue interactions responsible for skin and corneal injury are discussed along with preliminary results from these techniques. Further, we report on in vivo models which are considered to best represent human skin for laser tissue interaction studies. Additionally, in vitro models for corneal exposure are discussed as replacement models for in vivo corneal exposures.

Paper Details

Date Published: 14 June 1999
PDF: 4 pages
Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.350045
Show Author Affiliations
Thomas E. Johnson, Uniformed Services Univ. of the Health Sciences (United States)
Thomas A. Eggleston, Uniformed Services Univ. of the Health Sciences (United States)
David J. Fletcher, Uniformed Services Univ. of the Health Sciences (United States)
Ken Lopez, Uniformed Services Univ. of the Health Sciences (United States)
Pedro J. Rico, Uniformed Services Univ. of the Health Sciences (United States)
Michael A. Mitchell, Uniformed Services Univ. of the Health Sciences (United States)
William P. Roach, Uniformed Services Univ. of the Health Sciences (United States)


Published in SPIE Proceedings Vol. 3601:
Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; David H. Sliney; Gerhard J. Mueller; Gerhard J. Mueller; Andre Roggan; Andre Roggan; David H. Sliney, Editor(s)

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