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Proceedings Paper

Optical dosimetry in photodynamic therapy of human uterus and brain
Author(s): Steen J. Madsen; Lars Othar Svaasand; Henry Hirschberg; Yona Tadir; Bruce J. Tromberg
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Paper Abstract

Optical 'dose' is one of the fundamental parameters required in the design of an efficacious regimen of photodynamic therapy (PDT). The issues involved in delivering a sufficient optical dose to the human uterus and brain during PDT will be discussed. Specifically, measurements of optical properties and fluence rates in excised human uteri are presented. Measured fluence rates are compared to the predictions of a simple diffusion model and the clinical utility of the treatment is discussed. The delivery of light to brain tissue via a surgically implanted balloon applicator will also be considered. The time required to deliver and adequate dose is calculated based on known optical properties and diffusion theory.

Paper Details

Date Published: 14 June 1999
PDF: 9 pages
Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.350032
Show Author Affiliations
Steen J. Madsen, Univ. of Nevada/Las Vegas (United States)
Lars Othar Svaasand, Norwegian Univ. of Science and Technology (Norway)
Henry Hirschberg, Norwegian Radium Hospital (Norway)
Yona Tadir, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 3601:
Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; David H. Sliney; Gerhard J. Mueller; Gerhard J. Mueller; Andre Roggan; Andre Roggan; David H. Sliney, Editor(s)

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