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Proceedings Paper

Tissue ablation with the free-electron laser: contributions of wavelength and pulse structure
Author(s): Stephen R. Uhlhorn; Shannon Harrison; Hans Surya Pratisto; E. Duco Jansen
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Paper Abstract

The Vanderbilt free-electron laser provides a continuously tunable ((lambda) equals 2 - 10 micrometer) source of pulsed IR radiation with a pulse structure unlike those of conventional lasers (a macropulse of 4.5 ms consisting of a micropulse train of 1 ps pulses separated by 350 ps). Tuned to the vibrational mode of the amide-II band ((lambda) equals 6.45 micrometer), the laser is well suited for precise tissue ablation with reported minimal thermal and collateral tissue damage. However, the relative influences of the pulse structure and wavelength on tissue ablation is still not clear. The effects of different wavelengths ((lambda) equals 2.94, 3.36, and 6.45 micrometer) on tissue ablation were compared using pump-probe imaging of tissue phantoms while simultaneously laser-induced pressures were measured with a piezoelectric needle hydrophone. Bovine heart tissue was ablated in vitro using clinically relevant parameters and laser induced damage was examined histologically. The results of these experiments, and their implications will be discussed.

Paper Details

Date Published: 14 June 1999
PDF: 6 pages
Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.350020
Show Author Affiliations
Stephen R. Uhlhorn, Vanderbilt Univ. (United States)
Shannon Harrison, Vanderbilt Univ. (United States)
Hans Surya Pratisto, Vanderbilt Univ. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 3601:
Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; David H. Sliney; Gerhard J. Mueller; Gerhard J. Mueller; Andre Roggan; Andre Roggan; David H. Sliney, Editor(s)

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