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Proceedings Paper

Cavitation thresholds in the rabbit retinal pigmented epithelium
Author(s): Dale J. Payne; Thomas R. Jost; James J. Elliot; Brent Eilert; Laura Lott; Karen Lott; Gary D. Noojin; Richard A. Hopkins; Charles P. Lin; Benjamin A. Rockwell
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Paper Abstract

We performed measurements to examine retinal injury from laser pulses in the sub-nanosecond time regime. Both ex-vivo porcine and Dutch belted rabbit retinal pigment epithelium (RPE) models were used in conjunction with time resolved imaging to observe cavitation bubble formation. Included in this study are 3 ps, 300 fs, and 100 fs pulses at a wavelength of 580 nm, as well as 70 ps and 5 ns pulses at 532 nm. Threshold values varied between 37 mJ/cm2 and 50 mJ/cm2 across the range of pulse widths. Following laser irradiation cell viability was checked using a fluorescent dye marker (calcein). Our current results are compared to an earlier investigation using the artificial retina model.

Paper Details

Date Published: 14 June 1999
PDF: 5 pages
Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.350019
Show Author Affiliations
Dale J. Payne, Air Force Research Lab. (United States)
Thomas R. Jost, Air Force Research Lab. (United States)
James J. Elliot, Univ. of Southern California (United States)
Brent Eilert, Air Force Research Lab. (United States)
Laura Lott, Air Force Research Lab. (United States)
Karen Lott, Air Force Research Lab. (United States)
Gary D. Noojin, Litton TASC (United States)
Richard A. Hopkins, Air Force Research Lab. (United States)
Charles P. Lin, Wellman Labs. of Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)


Published in SPIE Proceedings Vol. 3601:
Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Gerhard J. Mueller; Andre Roggan; David H. Sliney; David H. Sliney; Gerhard J. Mueller; Andre Roggan, Editor(s)

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