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Proceedings Paper

Photodynamic treatment of the RIF-1 tumor with verteporfin with online monitoring of tissue oxygen using electron paramagnetic resonance oximetry
Author(s): Brian W. Pogue; Julia A. O'Hara; Ke Jian Liu; Tayyaba Hasan; Harold Swartz
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Paper Abstract

In this study, treatment of the RIF-1 tumor was examined with photodynamic therapy using Verteprofin (formerly benzoporphyrin derivative, BPD). The effects of two different optical dose rates were examined, with no detectable difference in the tumor regrowth time. Oxygen consumption during PDT could reliably be monitored with electron paramagnetic resonance (EPR) oximetry using an implanted paramagnetic material within the tumor. A reduction of the tumor pO2 was detected in the animals that were followed after treatment, suggesting that there was a compromise to the tumor vasculature that persisted throughout the measurements. At high total doses some of the tumors did not regrow. Altogether these results are indicative of the tumor destruction being caused by destruction of the blood vessels from the treatment.

Paper Details

Date Published: 14 June 1999
PDF: 7 pages
Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.349994
Show Author Affiliations
Brian W. Pogue, Dartmouth College, Wellman Labs. of Photomedicine, and Massachusetts General Hospital/Harv (United States)
Julia A. O'Hara, Dartmouth College Medical School (United States)
Ke Jian Liu, Dartmouth College Medical School (United States)
Tayyaba Hasan, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Harold Swartz, Dartmouth College Medical School (United States)

Published in SPIE Proceedings Vol. 3601:
Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; David H. Sliney; Gerhard J. Mueller; Gerhard J. Mueller; Andre Roggan; Andre Roggan; David H. Sliney, Editor(s)

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