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Proceedings Paper

Ultraviolet light attenuates vasospasm development: low-intensity 325-nm illumination in animal model
Author(s): Yuji Morimoto; Kanji Nakai; Tsunenori Arai; Katsuji Shima; Makoto Kikuchi
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Paper Abstract

We studied whether prophylactic low-intensity ultraviolet light (UV) irradiation reduces development of delayed cerebral vasospasm in rabbit model. Eleven rabbits had carotid angiography and placement of silicon sheaths around the right common carotid artery (CCA). Just before the placement, CCAs of 6 in the 11 animals were adventitiously exposed to UV (10 mJ/mm2) emitted from a helium-cadmium laser (wavelength equals 325 nm). Sheaths were filled with autologous blood in all of 11 animals. Vasospasm developed 24 to 48 hours (Day 2) later. The CCA luminal diameter without UV irradiation was 77% of the Day 0 state. The prophylactic laser treatment reduced the development of vasospasm, 90% of the Day 0 state. Histological examination of the treated CCA revealed extended smooth muscle cells. There was no endothelial damage. These results suggest that UV is effective for prophylaxis of cerebral vasospasm.

Paper Details

Date Published: 14 June 1999
PDF: 4 pages
Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); doi: 10.1117/12.349991
Show Author Affiliations
Yuji Morimoto, National Defense Medical College (Japan)
Kanji Nakai, National Defense Medical College (Japan)
Tsunenori Arai, National Defense Medical College (Japan)
Katsuji Shima, National Defense Medical College (Japan)
Makoto Kikuchi, National Defense Medical College (Japan)


Published in SPIE Proceedings Vol. 3601:
Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical
Steven L. Jacques; Gerhard J. Mueller; Andre Roggan; David H. Sliney; David H. Sliney; Gerhard J. Mueller; Andre Roggan, Editor(s)

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