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Proceedings Paper

Ultrasound catheters for circumferential cardiac ablation
Author(s): Chris J. Diederich; William H. Nau; Kevin Taylor; Mark T. Maguire; Guillermo Picazo; Madhuri Gangu; Michael D. Lesh
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Paper Abstract

The purpose of this study was to investigate performance characteristics of a catheter-based ultrasound applicator intended for circumferential ablation of cardiac tissue. The catheter design integrates a cylindrical ultrasound transducer within a distendable water filled balloon in order to produce circumferential lesions at sites in the atria (i.e., pulmonary vein ostia), intended for treatment of certain atrial arrhythmias. Biothermal simulations were used to investigate thermal lesion depths corresponding to variations in applied power, duration, balloon diameter, and acoustic efficiency. Prototype applicators of varying frequency (7 - 12 MHz) and balloon diameter were constructed and characterized using measurements of acoustic efficiency and rotational beam plots. In vitro studies were performed in freshly excised beef hearts to characterize the radial penetration, axial length, and angular uniformity of thermal lesions produced by these applicators. Selected applicators were tested in vivo within pulmonary veins, coronary sinus, and atrial appendage of canine and porcine hearts. These preliminary efforts have indicated that circumferential ablation of cardiac tissue using ultrasound balloon catheters is feasible, and devices between 7 - 12 MHz with balloon diameters of 1.5 - 2.0 cm are capable of producing uniform lesions between 1 - 5 mm depth or greater for treatment durations of 120 seconds or less.

Paper Details

Date Published: 19 May 1999
PDF: 9 pages
Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348743
Show Author Affiliations
Chris J. Diederich, Univ. of California/San Francisco (United States)
William H. Nau, Univ. of California/San Francisco (United States)
Kevin Taylor, Atrionix, Inc. (United States)
Mark T. Maguire, Atrionix, Inc. (United States)
Guillermo Picazo, Atrionix, Inc. (United States)
Madhuri Gangu, Univ. of California/San Francisco (United States)
Michael D. Lesh, Univ. of California/San Francisco (United States)


Published in SPIE Proceedings Vol. 3594:
Thermal Treatment of Tissue with Image Guidance
Thomas P. Ryan; Terence Z. Wong, Editor(s)

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