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Proceedings Paper

Technical considerations for Nd:YAG intracranial LITT in an iMRI unit
Author(s): Paul R. Morrison; Peter McLaren Black; Ferenc A. Jolesz
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Paper Abstract

Laser-induced interstitial thermal therapy (LITT) is a minimally invasive technique for tumor therapy. Light is transmitted to targeted tissue via a percutaneously placed optical fiber; heat generated by the absorption of the light produces a region of cell kill about the fiber's tip. Adequate monitoring of the spatial and temporal profile of the tissue temperature has always been considered key to suitable control of the process, since direct visualization is not possible. Magnetic resonance imaging (MRI) provides an unparalleled solution to the problem of monitoring LITT. Recently developed `open' interventional MRI (iMRI) units provide additional key characteristics (patient access; interactive scan plane control) which make the clinical testing of MRI-guided LITT feasible. An iMRI procedure room has been outfitted for Nd:YAG LITT procedures. Relevant technical highlights of treatments performed to date will be shared including room-layout, output calibration, limitations of the current system and considerations for the future. Clinical LITT has been of long-standing interest, possessing medical, engineering and physical problems to be solved. As it provides suitable monitoring capabilities, iMRI opens the field for earnest pursuit by experts not only for improved monitoring, but in establishing the clinical indications and effectiveness of the therapy.

Paper Details

Date Published: 19 May 1999
PDF: 10 pages
Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348740
Show Author Affiliations
Paul R. Morrison, Harvard Medical Laser Ctr./Harvard Medical School (United States)
Peter McLaren Black, Brigham and Women's Hospital/Harvard Medical School (United States)
Ferenc A. Jolesz, Brigham and Women's Hospital/Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 3594:
Thermal Treatment of Tissue with Image Guidance
Thomas P. Ryan; Terence Z. Wong, Editor(s)

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