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Proceedings Paper

MR-guided noninvasive thermal coagulation of in-vivo liver tissue using ultrasonic phased array
Author(s): Douglas R. Daum; Nadine Smith; Nathan McDannold; Kullervo H. Hynynen
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Paper Abstract

Magnetic resonance (MR) imaging was used to guide and monitor the thermal tissue coagulation of in vivo porcine tissue using a 256 element ultrasonic phased array. The array could coagulate tissue volumes greater than 2 cm3 in liver and 0.5 cm3 in kidney using a single 20 second sonication. This sonication used multiple focus fields which were temporally cycled to heat large tissue volumes simultaneously. Estimates of the coagulated tissue using a thermal dose threshold compare well with T2-weighted images of post sonication lesions. The overlapping large focal volumes could aid in the treatment of large tumor volumes which require multiple overlapping sonications. The ability of MR to detect the presence and undesirable thermal increases at acoustic obstacle such as cartilaginous and bony ribs is demonstrated. This could have a significant impact on the ability to monitor thermal treatments of the liver and other organs which are acoustically blocked.

Paper Details

Date Published: 19 May 1999
PDF: 9 pages
Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348738
Show Author Affiliations
Douglas R. Daum, Brigham and Women's Hospital/Harvard Medical School and Harvard-MIT (United States)
Nadine Smith, Brigham and Women's Hospital/Harvard Medical School (United States)
Nathan McDannold, Brigham and Women's Hospital/Harvard Medical School and Tufts Univ. (United States)
Kullervo H. Hynynen, Brigham and Women's Hospital/Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 3594:
Thermal Treatment of Tissue with Image Guidance
Thomas P. Ryan; Terence Z. Wong M.D., Editor(s)

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