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Proceedings Paper

Real time fiber optic detection of lethal thermal injury in vivo
Author(s): Sharon L. Thomsen; Jon A. Schwartz; Edward L. Sinofsky
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Paper Abstract

Accurate detection of the full extent of lethal thermal injury during and immediately after heating in interstitial thermal therapy is necessary to control the treatment volume while conserving surrounding tissues. A red zone of thermal injury forms in most tissues within thirty seconds as a result of physiologic response to heat in vivo. The red zone is formed by accumulation of blood due to hemostasis, hemorrhage and hyperhemia. The distinct outer boundary of this zone has been found to correspond to the outer boundary of tissue necrosis in rat livers examined 3 days after thermal coagulation. We have developed a minimally invasive fiberoptic probe that can detect this boundary using changes in white light absorption spectra of hemoglobin compared to native tissue. Decreased reflected light intensity marks the development of the outer boundary of the red thermal damage zone that is a hallmark of the full extent of lethal thermal damage.

Paper Details

Date Published: 19 May 1999
PDF: 6 pages
Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); doi: 10.1117/12.348728
Show Author Affiliations
Sharon L. Thomsen, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jon A. Schwartz, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Edward L. Sinofsky, Rare Earth Medical, Inc. (United States)


Published in SPIE Proceedings Vol. 3594:
Thermal Treatment of Tissue with Image Guidance
Thomas P. Ryan; Terence Z. Wong, Editor(s)

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