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Proceedings Paper

Quantification of the progression of CMV infection as observed from retinal angiograms in patients with AIDS
Author(s): Djamel Brahmi; Nathalie Cassoux; Camille Serruys; Alain Giron; Phuc Lehoang; Bernard Fertil
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Paper Abstract

To support ophthalmologists in their daily routine and enable the quantitative assessment of progression of Cytomegalovirus infection as observed on series of retinal angiograms, a methodology allowing an accurate comparison of retinal borders has been developed. In order to evaluate accuracy of borders, ophthalmologists have been asked to repeatedly outline boundaries between infected and noninfected areas. As a matter of fact, accuracy of drawing relies on local features such as contrast, quality of image, background..., all factors which make the boundaries more or less perceptible from one part of an image to another. In order to directly estimate accuracy of retinal border from image analysis, an artificial neural network (a succession of unsupervised and supervised neural networks) has been designed to correlate accuracy of drawing (as calculated form ophthalmologists' hand-outlines) with local features of the underlying image. Our method has been applied to the quantification of CMV retinitis. It is shown that accuracy of border is properly predicted and characterized by a confident envelope that allows, after a registration phase based on fixed landmarks such as vessel forks, to accurately assess the evolution of CMV infection.

Paper Details

Date Published: 21 May 1999
PDF: 9 pages
Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348649
Show Author Affiliations
Djamel Brahmi, INSERM (France)
Nathalie Cassoux, Service d'Ophtalmologie/Hopital de la Pitie-Salpetriere (France)
Camille Serruys, INSERM (France)
Alain Giron, INSERM (France)
Phuc Lehoang, INSERM (France)
Bernard Fertil, Service d'Ophtalmologie/Hopital de la Pitie-Salpetriere (France)

Published in SPIE Proceedings Vol. 3661:
Medical Imaging 1999: Image Processing
Kenneth M. Hanson, Editor(s)

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