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Proceedings Paper

MRI-SPECT image registration using multiple MR pulse sequences to examine osteoarthritis of the knee
Author(s): John Andrew Lynch; Charles G. Peterfy; David L. White; Randall A. Hawkins; Harry K. Genant
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Paper Abstract

We have examined whether automated image registration can be used to combine metabolic information from SPECT knee scans with anatomical information from MRI. Ten patients, at risk of developing OA due to meniscal surgery, were examined. 99mTc methyldiphosphonate SPECT, T2-weighted fast spin echo (FSE) MRI, and T1-weighted, 3D fat-suppressed gradient recalled echo (SPGR) MRI images were obtained. Registration was performed using normalized mutual information. For each patient, FSE data was registered to SPGR data, providing a composite MRI image with each voxel represented by two intensities (ISPGR, IFSE). Modifications to the registration algorithm were made to allow registration of SPECT data (one intensity per voxel) to composite MRI data (2 intensities per voxel). Registration sources was assessed by visual inspection of uptake localization over expected anatomical locations, and the absence of uptake over unlikely sites. Three patients were discarded from SPECT-MRI registration tests since they had metallic artifacts that prevented co-registration of MR data. Registration of SPECT to SPGR or FSE data alone proved unreliable, with less than 50% of attempts succeeding. The modified algorithm, treating co-registered SPGR and FSE data as a two-value-per-voxel image, proved most reliable, allowing registration of all patients with no metallic artifacts on MRI.

Paper Details

Date Published: 21 May 1999
PDF: 10 pages
Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348626
Show Author Affiliations
John Andrew Lynch, Univ. of California/San Francisco (United States)
Charles G. Peterfy, Univ. of California/San Francisco (United States)
David L. White, Univ. of California/San Francisco (United States)
Randall A. Hawkins, Univ. of California/San Francisco (United States)
Harry K. Genant, Univ. of California/San Francisco (United States)


Published in SPIE Proceedings Vol. 3661:
Medical Imaging 1999: Image Processing
Kenneth M. Hanson, Editor(s)

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