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Proceedings Paper

New experimental results in atlas-based brain morphometry
Author(s): James C. Gee; Brian A. Fabella; Siddharth E. Fernandes; Bruce I. Turetsky; Ruben C. Gur; Raquel E. Gur
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Paper Abstract

In a previous meeting, we described a computational approach to MRI morphometry, in which a spatial warp mapping a reference or atlas image into anatomic alignment with the subject is first inferred. Shape differences with respect to the atlas are then studied by calculating the pointwise Jacobian determinant for the warp, which provides a measure of the change in differential volume about a point in the reference as it transforms to its corresponding position in the subject. In this paper, the method is used to analyze sex differences in the shape and size of the corpus callosum in an ongoing study of a large population of normal controls. The preliminary results of the current analysis support findings in the literature that have observed the splenium to be larger in females than in males.

Paper Details

Date Published: 21 May 1999
PDF: 8 pages
Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348616
Show Author Affiliations
James C. Gee, Univ. of Pennsylvania (United States)
Brian A. Fabella, Univ. of Pennsylvania (United States)
Siddharth E. Fernandes, Univ. of Pennsylvania (United States)
Bruce I. Turetsky, Univ. of Pennsylvania (United States)
Ruben C. Gur, Univ. of Pennsylvania (United States)
Raquel E. Gur, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 3661:
Medical Imaging 1999: Image Processing
Kenneth M. Hanson, Editor(s)

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