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Proceedings Paper

Detecting small anatomical change with 3D serial MR subtraction images
Author(s): Mark Holden; Erica R. E. Denton; J. M. Jarosz; T. C.S. Cox; Colin Studholme; David John Hawkes; Derek L.G. Hill
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Paper Abstract

Spoiled gradient echo volume MR scans were obtained from 5 growth hormone (GH) patients and 6 normal controls. The patients were scanned before treatment and after 3 and 6 months of GH therapy. The controls were scanned at similar intervals. A calibration phantom was scanned on the same day as each subject. The phantom images were registered with a 9 degree of freedom algorithm to measure scaling errors due to changes in scanner calibration. The second and third images were each registered with a 6 degree of freedom algorithm to the first (baseline) image by maximizing normalized mutual information, and transformed, with and without scaling error correction, using sinc interpolation. Each registered and transformed image had the baseline image subtracted to generate a difference image. Two neuro-radiologists were trained to detect structural change with difference images containing synthetic misregistration and scale changes. They carried out a blinded assessment of anatomical change for the unregistered; aligned and subtracted; and scale corrected, aligned and subtracted images. The results show a significant improvement in the detection of structural change and inter-observer agreement when aligned and subtracted images were used instead of unregistered ones. The structural change corresponded to an increase in brain: CSF ratio.

Paper Details

Date Published: 21 May 1999
PDF: 12 pages
Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348594
Show Author Affiliations
Mark Holden, Guy's Hospital (United Kingdom)
Erica R. E. Denton, King's College Hospital (United Kingdom)
J. M. Jarosz, King's College Hospital (United Kingdom)
T. C.S. Cox, Institute of Neurology/Univ. College London (United Kingdom)
Colin Studholme, Yale Univ. School of Medicine (United States)
David John Hawkes, Guy's Hospital (United Kingdom)
Derek L.G. Hill, Guy's Hospital (United Kingdom)


Published in SPIE Proceedings Vol. 3661:
Medical Imaging 1999: Image Processing
Kenneth M. Hanson, Editor(s)

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