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Proceedings Paper

Measurement of hippocampal volume changes in serial MRI scans
Author(s): Julia Anne Schnabel; Louis Lemieux; U. C. Wieshmann; Simon Robert Arridge
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Paper Abstract

We present a new method for the detection and measurement of volume changes in human hippocampi in serial Magnetic Resonance Imaging (MRI). The method follows a two-stage approach: (1) precise co-registration and intensity matching of the initial (baseline) and follow-up scan, and (2) refinement and segmentation propagation of the hippocampi outlines drawn in the baseline scan by an expert observer to the matched scan (co-registered and intensity matched follow- up scan of the time series). The first step is performed using MRreg, a rigid registration tool based on cross-correlation and intensity matching, and the second step makes use of the concept of active contour models for tracking the hippocampi outlines in the time series.

Paper Details

Date Published: 21 May 1999
PDF: 10 pages
Proc. SPIE 3661, Medical Imaging 1999: Image Processing, (21 May 1999); doi: 10.1117/12.348535
Show Author Affiliations
Julia Anne Schnabel, Univ. Hospital Utrecht and Univ. College London (United Kingdom)
Louis Lemieux, Institute of Neurology/Univ. College London (United Kingdom)
U. C. Wieshmann, Chalfont Ctr. for Epilepsy (United Kingdom)
Simon Robert Arridge, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 3661:
Medical Imaging 1999: Image Processing
Kenneth M. Hanson, Editor(s)

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