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Proceedings Paper

Monitoring physiological function by detection of exogenous fluorescent contrast agents
Author(s): Richard B. Dorshow; Joseph E. Bugaj; Samuel I. Achilefu; Raghavan Rajagopalan; Arthur H. Combs
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Paper Abstract

An invasive in vivo fluorescence detection scheme was employed to continuously monitor exogenous dye clearance from the vasculature. This invasive physiological monitoring technique was successfully demonstrated in a rabbit model. A commercially available catheter with embedded fiber optics was employed to transmit the excitation light and detect the emitted fluorescence. The clearance of indocyanine green, known to be exclusively cleared from the blood stream by the liver, was determined invasively. The clearance curves determined by this novel invasive method replicated the clearance curves in the same animals employing the non- invasive method established previously. Thus, the feasibility of a new invasive method for physiological function assessment was established.

Paper Details

Date Published: 17 May 1999
PDF: 7 pages
Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); doi: 10.1117/12.348383
Show Author Affiliations
Richard B. Dorshow, Mallinckrodt Inc. (United States)
Joseph E. Bugaj, Mallinckrodt Inc. (United States)
Samuel I. Achilefu, Mallinckrodt Inc. (United States)
Raghavan Rajagopalan, Mallinckrodt Inc. (United States)
Arthur H. Combs, Mallinckrodt Inc. (United States)


Published in SPIE Proceedings Vol. 3599:
Optical Diagnostics of Biological Fluids IV
Alexander V. Priezzhev; Toshimitsu Asakura, Editor(s)

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