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Proceedings Paper

Heat-induced changes in optical properties of human whole blood in vitro
Author(s): Vladimir Yu. Baranov; Dmitriy I. Chekhov; Alexei G. Leonov; Pavel G. Leonov; Olga M. Ryaboshapka; S. Yu. Semenov; Robert Splinter; Robert H. Svenson; George P. Tatsis
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Paper Abstract

The effect of anomalous optical behavior of biological tissue at high-intensity laser irradiation can be caused by heat- induced changes in optical properties of consisting components, mainly muscle tissue and blood. We registered the spectral transmission of fresh human whole blood and serum samples in the wavelength range of 300 - 700 nm at the heating of samples in the temperature range of 35 - 65 degrees Celsius. The results showed an increase of 10 - 15% in the transmission of blood serum at the temperature rising up to 50 - 60 degrees Celsius. In the case of diluted whole blood a sharply enhanced transmission was observed at the temperature of 56 - 60 degrees Celsius, while further heating resulted in a decreased transmission down to the initial level. The significant changes (of a three orders of magnitude) in the transmission of whole blood at the wavelength of Nd:YAG laser (1064 nm) were observed. The obtained results can be considered as one of the possible explanations of the anomalous light distribution in certain tissues.

Paper Details

Date Published: 17 May 1999
PDF: 8 pages
Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); doi: 10.1117/12.348378
Show Author Affiliations
Vladimir Yu. Baranov, Kurchatov Institute (Russia)
Dmitriy I. Chekhov, Moscow Institute of Physics and Technology (Russia)
Alexei G. Leonov, Moscow Institute of Physics and Technology (Russia)
Pavel G. Leonov, Industrial Lasers Research and Development Ctr. (Russia)
Olga M. Ryaboshapka, Industrial Lasers Research and Development Ctr. (Russia)
S. Yu. Semenov, Kurchatov Institute (Russia)
Robert Splinter, Carolinas Medical Ctr. (United States)
Robert H. Svenson, Carolinas Medical Ctr. (United States)
George P. Tatsis, Carolinas Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 3599:
Optical Diagnostics of Biological Fluids IV
Alexander V. Priezzhev; Toshimitsu Asakura, Editor(s)

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