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Proceedings Paper

Determination of the optical properties of a human brain tumor using a new microspectrophotometric technique
Author(s): Stefan Willmann; Albert Terenji; Ilya V. Yaroslavsky; Thomas Kahn M.D.; Peter Hering; Hans-Joachim Schwarzmaier M.D.
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Paper Abstract

We have developed a new technique to determine the optical properties of turbid media on a spatial scale of several 100 micrometers . This technique is based on transmission measurements into three different solid angles using a microspectrophotometer. An inverse Monte-Carlo simulation was employed to extract the optical properties from the sample under investigation. In this study, we investigated the optical properties of human brain tumor tissue. The transmission measurements were performed in the wavelength range from 400 nm to 800 nm for one spot on the sample. In addition, the histological inhomogeneity of the brain tumor was evaluated by probing the optical properties of different spots on the sample at a fixed wavelength. The resulting scattering coefficients varied between 6.0 and 7.9 mm-1, the absorption coefficients between 0.50 and 0.92 mm-1, and the anisotropy factors between 0.867 and 0.895. These result suggest that this microspectrophotometric technique is suitable to determine the optical properties of an inhomogeneous turbid media as for example a human brain tumor sample with a spatial resolution unattainable by conventional spectrophotometric techniques.

Paper Details

Date Published: 30 April 1999
PDF: 7 pages
Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); doi: 10.1117/12.347503
Show Author Affiliations
Stefan Willmann, Heinrich-Heine-Univ. (Germany)
Albert Terenji, Heinrich-Heine-Univ. (Germany)
Ilya V. Yaroslavsky, Heinrich-Heine-Univ. and Louisiana State Univ. (United States)
Thomas Kahn M.D., Heinrich-Heine-Univ. (Germany)
Peter Hering, Heinrich-Heine-Univ. (Germany)
Hans-Joachim Schwarzmaier M.D., German National Research Ctr. for Information Technology (Germany)

Published in SPIE Proceedings Vol. 3598:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III
Valery V. Tuchin; Joseph A. Izatt, Editor(s)

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