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Proceedings Paper

OCT imaging of osteoarthritic cartilage: structure, polarization sensitivity, and clinical feasibility
Author(s): Xing De Li; Jurgen Herrmann; Ravi K. Ghanta; Constantinos Pitris; Wolfgang Drexler; Christine Jesser; Debra L. Stamper; David Golden; Scott Martin; James G. Fujimoto; Mark E. Brezinski
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Paper Abstract

This work demonstrates the feasibility of OCT for identifying early osteoarthritic pathology. In addition to structural abnormalities, changes in collagen fiber organization, an indicator of very early osteoarthritis, were assessed with a polarization sensitive OCT system. A portable, real time, modular OCT system, suitable for both laboratory and clinical settings, has been developed. Preliminary in vivo imaging results obtained during partial knee replacement surgery are discussed.

Paper Details

Date Published: 30 April 1999
PDF: 6 pages
Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); doi: 10.1117/12.347484
Show Author Affiliations
Xing De Li, Massachusetts Institute of Technology (United States)
Jurgen Herrmann, Massachusetts Institute of Technology (United States)
Ravi K. Ghanta, Massachusetts Institute of Technology (United States)
Constantinos Pitris, Massachusetts Institute of Technology (United States)
Wolfgang Drexler, Massachusetts Institute of Technology (Austria)
Christine Jesser, Massachusetts General Hospital and Harvard Medical School (United States)
Debra L. Stamper, King's College (United States)
David Golden, Brigham and Women's Hospital/Harvard Medical School (United States)
Scott Martin, Brigham and Women's Hospital/Harvard Medical School (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)
Mark E. Brezinski, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 3598:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III
Valery V. Tuchin; Joseph A. Izatt, Editor(s)

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